The most popular PDEs are PDE5. Since cGMP produced by activation of this cell signalling pathway is central to a lot of physiological processes, PDE5 inhibition has been shown to exert a multitude of therapeutic roles, from erectile dysfunction to pulmonary hypertension. These inhibitors are designed to inhibit PDE5, but they are not as selective or affine…

Proliferating cell nuclear antigen (PCNA) is found in every eukaryotic organism and archaea. PCNA is a crucial protein responsible for DNA replication and cell cycle control. PCNA is a DNA polymerase d processing factor and it is also involved in essential cellular functions such as chromatin remodeling, DNA repair, sister chromatid adhesion, and cell cycle regulation….